John Lloyd Cruz and Toni Gonzaga were both hailed as SM Cinema's Box-Office King and Queen. Their movie, My Amnesia Girl, topped the list of highest grossing local films screened from January 1, 2010 to December 31, 2010 in all SM Cinema branches.
Here is the complete list of the highest grossing local films screened in all SM Cinema branches in 2010.
- My Amnesia Girl ( John Lloyd Cruz and Toni Gonzaga)
- Miss You Like Crazy (John Llyod Cruz and Bea Alonzo)
- Here Comes the Bride (Eugene Domingo)
- Petrang Kabayo (Vice Ganda)
- Si Agimat at si Enteng Kabisote (Vic Sotto and Bong Revilla)
- Ang Tanging Ina Mo (Last Na 'To!) - Ai Ai Delas Alas
- Paano na Kaya (Kim Chui and Gerald Anderson)
- Babe I Love You (Sam Milby and Anne Curtis)
- Hating Kapatid (Judy Ann Santos and Sarah Geronimo)
- You to Me are Everything (Marian Rivera and Ding Dong Dantes)